Can You Be Addicted to More Than One Substance at a Time? | Polysubstance Use Disorder
Can You Be Addicted to More Than One Substance at a Time?
Written by Benjamin Zohar , NCACIP
Publication Date: 20 November 2025
Reviewed by Brandon McNally, RN
Absolutely yes. Polysubstance use disorder—or addiction to more than one substance at a time—is a common and clinically significant condition affecting millions of Americans, including many in New York.
What Is Polysubstance Use Disorder?
Polysubstance use refers to the use of two or more psychoactive substances in combination, either simultaneously or sequentially, often to enhance effects, manage withdrawal, or cope with...