Cocaine exerts its behavioral stimulant effects by facilitating synaptic actions of neurotransmitters such as dopamine and serotonin. It is also neurotoxic and broadly cytotoxic, leading to overdose deaths. We demonstrate that the...
Working with mice, researchers at Johns Hopkins have contributed significant new evidence to support the idea that high doses of cocaine kill brain cells by triggering overactive autophagy, a process in which cells literally digest their...
This is one of 25 cells in the Alcohol Treatment Matrix. The cell discusses key research relating to the roles of psychosocial therapies in local treatment systems. In particular, their role in creating a cost-effective mix of services...
New research supported by the National Institute on Drug Abuse (NIDA) has found through a comparison of treatment approaches for opioid dependence that, in an emergency setting, combining the medication buprenorphine with on-going care is...
What is already known about this topic?
Fentanyl has a growing presence in the illicit drug market and is involved in an increasing proportion of opioid overdose deaths.
What is added by this report?
Approximately two thirds of...
Alcohol use during pregnancy is the direct cause of fetal alcohol syndrome (FAS). We aimed to estimate the prevalence of alcohol use during pregnancy and FAS in the general population and, by linking these two indicators...
Studies have shown that alcohol may play a role in more that 13% of deaths resulting from infectious diseases, including HIV.
Evidence suggests that alcohol consumption negatively affects the fight against HIV primarily by:
New research published in the journal Translational Psychiatry has found that LSD reduces activity in the region of the brain responsible for negative emotions such as fear.
The researchers call this the drug’s ‘de-frightening effect’ and...
