All Resources for 'Community-Based Prevention'

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Jolien van Aar University of Amsterdam

Patty Leijten University of Amsterdam; Bram Orobio...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Ghaffar Hurtado University of Maryland

Javiera Monardez-Popelka University of Minnesota...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Christopher Mehus University of Minnesota- Twin Cities

Elizabeth A Wieling University of...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Truls Tømmerås Norwegian Center for Child Behavioral Development

Terje Gunnar Ogden The...

This abstract was presented at the 2018 Society for Prevention Research Annual Meeting which was held May 29 – June 1, 2018 in Washington, DC, US.

Diego Garcia-Huidobro Pontificia Universidad Catolica de Chile

Luis OrtegaUniversity of...

RESUMEN: El objetivo de este trabajo es describir la situación actual de la salud mental en Ecuador. En Ecuador, aunque el modelo de salud mental comunitaria está integrado en los servicios de atención primaria de salud desde hace una...

A new study examines mortality risks related to alcohol use from approximately 600,000 drinkers of differing levels, in 83 prospective studies and across 19 countries.

One important finding from the study is that the initial threshold of...

Abstract The ventral tegmental area (VTA) evaluates salience of environmental stimuli and provides dopaminergic innervation to many brain areas affected by acute and chronic ethanol exposure. While primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the VTA in aversion as well. Ethanol actions in the VTA may trigger neuroadaptation resulting in reduction of the aversive responses to alcohol and a relative increase in the rewarding responses. In searching for effective pharmacotherapies for the treatment of alcohol abuse and alcoholism, recognition of this imbalance may reveal novel strategies. In addition to conventional receptor/ion channel pharmacotherapies, epigenetic factors that control neuroadaptation to chronic ethanol treatment can be targeted as an avenue for development of therapeutic approaches to restore the balance. Furthermore, when exploring therapies to address reward/aversion imbalance in the action of alcohol in the VTA, sex differences have to be taken into account to ensure effective treatment for both men and women. These principles apply to a VTA-centric approach to therapies, but should hold true when thinking about the overall approach in the development of neuroactive drugs to treat alcohol use disorders. Although the functions of the VTA itself are complex, it is a useful model system to evaluate the reward/aversion imbalance that occurs with ethanol exposure and could be used to provide new leads in the efforts to develop novel drugs to treat alcoholism.