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Repeated Exposure to the “Spice” Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT1A Receptor Stimulation in Male Rats
Naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) is a synthetic compound found in psychoactive “spice” products that activates cannabinoid receptors. Preclinical evidence suggests that exposure to synthetic cannabinoids increases 5...
National Trends in Alcohol Consumption in Mexico
Abstract:
Introduction: Worldwide, binge drinking of alcohol has increased, especially among young people. In Mexico, various epidemiological sources allow us to account for the growth this pattern of consumption has had. Given this...
The Influence of Hazardous Drinking on Psychological Functioning, Stress and Sleep during and after Treatment in Patients with Mental Health Problems
Abstract
Objectives: Hazardous drinking could negatively affect health and lead to alcohol use disorders, but it is unclear how hazardous drinking affects treatment outcomes of depression and anxiety and stress-related mental health...
Guide to treatment and social integration in the field of addictions
The aim of this guide is to facilitate the understanding of the problem of adolescent substance use, as well as present practices based on clinical evidence more effective guidance and intervention with this population.
The guide is...
Nabiximols Combined with Motivational Enhancement/Cognitive Behavioral Therapy for the Treatment of Cannabis Dependence
Abstract
Background
The current lack of pharmacological treatments for cannabis use disorder (CUD) warrants novel approaches and further investigation of promising pharmacotherapy. We previously showed that nabiximols (27 mg/ml Δ9...
Measuring Treatment Outcomes in Gambling Disorders
Abstract
Background and Aims
Considerable variation of outcome variables used to measure recovery in the gambling treatment literature has precluded effective cross-study evaluations and hindered the development of best-practice treatment...
Rural and Appalachian Disparities in Neonatal Abstinence Syndrome Incidence and Access to Opioid Abuse Treatment
Abstract
Objective
Incidence of neonatal abstinence syndrome (NAS) is increasing due to the rise in opioid use. Rural states like Kentucky have been disproportionally impacted by opioid abuse, and this study determines NAS burden...
Contemporary Routes of Cannabis Consumption: A Primer for Clinicians
Abstract
Although cannabis use is federally prohibited, medical cannabis is legal in some form in 30 states and the District of Columbia, and recreational use is legal in 8 states and the District of Columbia. The increasing legal...
Reported Theory Use by Digital Interventions for Hazardous and Harmful Alcohol Consumption, and Association with Effectiveness
ABSTRACT
Background: Applying theory to the design and evaluation of interventions is likely to increase effectiveness and improve the evidence base from which future interventions are developed, though few interventions report this.
Obje...
Effectiveness Bank Matrix Cell: Can Medications Make It *Too* Easy to Recover?
Drug-based treatments dominate opiate addiction treatment but are far from universally accepted. Referring to chemical ‘solutions’ to addiction, the ‘bite’ commentary on this cell ends with the “curious possibility that precisely because a...
Intervention guide mhGAP for mental, neurological disorders and substance use in the level of non-specialized health care. Version 2.0
Mental, neurological and substance (MNS) disorders are very common and represent a large burden of disease and disability around the world. There remains a wide gap between the capacity of health systems and resources, between what is...
mhGAP Intervention Guide - Version 2.0 for Mental, Neurological and Substance Use Disorders in Non-Specialized Health Settings
Overview
This is the second version (2016) of the mhGAP Intervention Guide (mhGAP-IG) for mental, neurological and substance use (MNS) disorders in non-specialist health settings. It is for use by doctors, nurses, other health workers as...
Risk of Violence in Drug Rehabilitation Centers
Abstract
Background
In 2009, Mexico reformed its health law to partially decriminalize drug possession considered for personal use and to increase mandatory referrals to certified drug rehabilitation centers in lieu of incarceration...
Clinical practice guidelines: treatment of alcohol withdrawal, 2 Edition
This document responds to the need to have tools that are standardized for the comprehensive management of alcohol withdrawal syndrome in clinical practice. The working group that developed this document was based on the clinical practice...
The Health and Social Effects of Nonmedical Cannabis Use
Foreword
Cannabis is globally the most commonly used psychoactive substance under international control. In 2013, an estimated 181.8 million people aged 15-64 years used cannabis for nonmedical purposes globally (UNODC, 2015). There is an...
Reduction of Mortality Following Better Detection of Hypertension and Alcohol Problems in Primary Health Care in Spain
Abstract
Through a simulation study, we estimated the potential effects of better detection of hypertension and improved screening for alcohol problems with subsequent interventions. Results showed that if 50% of Spanish males between 40...
Reduction of mortality through improved detection of high blood pressure and problems with alcohol in primary health care in Spain
Overview
The potential benefits that can lead to an improvement in the detection and treatment of high blood pressure and alcohol-related problems are studied through a simulation. The results show that if Spanish 50% of men between 40 and...
Contribution of Alcohol Use Disorders to the Burden of Dementia in France 2008–13
Summary
Background
Dementia is a prevalent condition, affecting 5–7% of people aged 60 years and older, and a leading cause of disability in people aged 60 years and older globally. We aimed to examine the association between alcohol use...
Women and drug treatment
Guide to clinical advice for treatment and rehabilitation programs in drugs in specific population of adult women.
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